• A unifying theory of aging

    January 3, 2007: by Bill Sardi

    Longevinex® is more than resveratrol

    Ingredients in Longevinex® address the many theories of aging.

    While resveratrol has recently gained widespread public and scientific attention for it age prolonging qualities, Longevinex® is a unique multi-ingredient dietary supplement that is more than just resveratrol.

    The ingredients in Longevinex® are designed to address five major theories of aging: the free radical/antioxidant theory, the hormonal theory (estrogen/testosterone), the mitochondrial (cell energy) theory, the cell cleansing or autophagy theory, and the metabolic, calorie restriction/Sirtuin gene activation theory.

    There is another theory of aging, also addressed by the ingredients in Longevinex®, which may supercede and better explain other theories of aging.  It is proposed here.

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  • A unifying theory of aging, part 2

    : by Bill Sardi

    Longevinex® is more than resveratrol

    The mouse experiment

    Animal experiments provide evidence for the iron overload theory of aging.

    A research experiment conducted at the University of Texas Health Science center in San Antonio, Texas, is telling.  The level of oxidation in various organs of mice was measured at 6, 12, and 24 months of age.  The more food these animals consumed, the greater the accumulation of iron in their tissues, and the greater the amount of oxidation (aging) in these tissues.  The accumulation of iron in these animals did not appear till full growth had been achieved, or after 355 days.  After that time, iron in the liver increased by 140 percent and in the kidneys by 44 percent.  The greatest buildup of iron in these animals with advancing age was measured in the liver and brain.   Dietary restriction markedly reduces oxidation and iron levels in tissues

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  • A unifying theory of aging, part 3

    : by Bill Sardi

    Longevinex® is more than resveratrol

    Iron control

    The human body has an elaborate system to control iron.  Iron that is unbound, that is not attached to proteins (free iron), is the most dangerous form of iron.  Unbound iron produces the hydroxyl radical, known as the most destructive species of free radical in the body.  Indeed, oxidative injury is considered a major factor in accelerated aging.

    The majority of iron in the body is bound to the red hemoglobin pigment in red blood cells.  As long as it is bound, it poses no problem.  In a controlled fashion iron is transported to the bone marrow and dropped off for production of new red blood renewal.

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  • A unifying theory of aging, part 4

    : by Bill Sardi

    Longevinex® is more than resveratrol

    Another theory of aging: cell cleansing

    Another overlapping theory of aging is the “cell cleansing” theory.  Living cells must rid themselves of debris.  Cell bodies called lysosomes literally digest and recycle cellular debris, a process that even provides a source of cellular energy (food) in the event of starvation.

    This cellular cleansing process is called autophagy.  Activation of autophagy can increase longevity. With advancing age, the garbage-digesting lysosomes and the energy-producing mitochondria in living cells eventually become burdened with excessive iron and calcium as well as other metallic minerals.  Aged lysomes progressively fail to perform cell cleansing chores and the cell dies.

    The failure of the lysosomes to continually cleanse cells of debris is now considered a form of programmed cell death.

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  • A unifying theory of aging, References

    : by Bill Sardi

    Longevinex® is more than resveratrol

    References

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