July 9, 2013: by longevinex.com
Las Vegas, NV (July 9, 2013) – In an effort to help ensure its product is not removed from the marketplace by onerous requirements stipulated by regulatory agencies or by covert efforts to undermine its product quality, Longevinex® announces today its proprietary red wine anti-aging capsules have passed stringent sub-acute toxicity testing, a requirement for further human testing.
Longevinex® red wine capsules did not produce significant toxic side effects or mortality in laboratory mice at human equivalent doses of 3500 and 7000 milligrams per day (~10-20 oral capsules/day) in testing conducted under the supervision of Hannah R. Vasanthi PhD, at the Department of Biotechnology, Pondicherry University, India. A complete report was published in the journal of Food & Chemical Toxicology.
March 13, 2013: by Bill Sardi
…. mice fed a normal-calorie diet did not live longer, the initial experiment to show the primary gene target for resveratrol was flawed and a huge dose of this red wine molecule barely improved measurable health parameters among metabolic disease (diabetes) patients and induced kidney failure among terminal cancer patients, causing the sponsor of a resveratrol-based drug to halt all research and development.
December 12, 2012: by Bill Sardi
MicroRNA studies conducted at the National Institutes of Health reveal one particular brand of resveratrol-based pill, Longevinex®, exhibits a distinctive gene activity pattern apart from plain resveratrol. In particular, Longevinex strongly inhibits production of gene proteins produced when tissues are deprived of oxygen and subsequently develop new abnormal blood vessels in an attempt to deliver O2 to tissues.
In the study published in PLoS ONE, just two microRNA represented over 90% of Longevinex’ broad gene activity. (Micro RNA are small RNA molecules that regulate gene activity.)
January 3, 2007: by Bill Sardi
While resveratrol has recently gained widespread public and scientific attention for it age prolonging qualities, Longevinex® is a unique multi-ingredient dietary supplement that is more than just resveratrol.
The ingredients in Longevinex® are designed to address five major theories of aging: the free radical/antioxidant theory, the hormonal theory (estrogen/testosterone), the mitochondrial (cell energy) theory, the cell cleansing or autophagy theory, and the metabolic, calorie restriction/Sirtuin gene activation theory.
There is another theory of aging, also addressed by the ingredients in Longevinex®, which may supercede and better explain other theories of aging. It is proposed here.
: by Bill Sardi
Animal experiments provide evidence for the iron overload theory of aging.
A research experiment conducted at the University of Texas Health Science center in San Antonio, Texas, is telling. The level of oxidation in various organs of mice was measured at 6, 12, and 24 months of age. The more food these animals consumed, the greater the accumulation of iron in their tissues, and the greater the amount of oxidation (aging) in these tissues. The accumulation of iron in these animals did not appear till full growth had been achieved, or after 355 days. After that time, iron in the liver increased by 140 percent and in the kidneys by 44 percent. The greatest buildup of iron in these animals with advancing age was measured in the liver and brain. Dietary restriction markedly reduces oxidation and iron levels in tissues
: by Bill Sardi
The human body has an elaborate system to control iron. Iron that is unbound, that is not attached to proteins (free iron), is the most dangerous form of iron. Unbound iron produces the hydroxyl radical, known as the most destructive species of free radical in the body. Indeed, oxidative injury is considered a major factor in accelerated aging.
The majority of iron in the body is bound to the red hemoglobin pigment in red blood cells. As long as it is bound, it poses no problem. In a controlled fashion iron is transported to the bone marrow and dropped off for production of new red blood renewal.
: by Bill Sardi
Another overlapping theory of aging is the “cell cleansing” theory. Living cells must rid themselves of debris. Cell bodies called lysosomes literally digest and recycle cellular debris, a process that even provides a source of cellular energy (food) in the event of starvation.
This cellular cleansing process is called autophagy. Activation of autophagy can increase longevity. With advancing age, the garbage-digesting lysosomes and the energy-producing mitochondria in living cells eventually become burdened with excessive iron and calcium as well as other metallic minerals. Aged lysomes progressively fail to perform cell cleansing chores and the cell dies.
The failure of the lysosomes to continually cleanse cells of debris is now considered a form of programmed cell death.
: by Bill Sardi