Pronounced long-jev-in-ex
The Official Website
Pronounced long-jev-in-ex
The Official Website
November 9, 2010: by longevinex.com
Las Vegas, NV (November 8, 2010) – According to the latest published research, the heart-healthiest laboratory animals in the world are taking Longevinex®, a red wine pill dietary supplement.
Researchers gave cholesterol-fed rabbits Longevinex®, a proprietary blend of red wine molecules (resveratrol, quercetin, ferulic acid) plus rice bran IP6 and vitamin D3, and found this dietary supplement:
Rabbit owners can feed their pets Longevinex®, knowing they will be the heart-healthiest animals in the world. The study, entitled “Reduction of blood cholesterol and ischemic injury in the hypercholesteromic rabbit with modified resveratrol, Longevinex®,” was published in the journal of Molecular & Cellular Biochemistry. To learn more about Longevinex®, click here. #### © 2010 Resveratrol Partners LLC, not for posting on other websites.
Heart-Healthy Effects of Longevinex® in Cholesterol-Fed Laboratory AnimalsMolecular & Cellular Biochemistry 2010 Nov 4 online |
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|
Measured Parameter |
Non-cholesterol-fed |
Cholesterol-fed + Longevinex® |
| Circulating total cholesterol at 32 weeks |
26 |
12.5 |
| Arterial plaque |
84 |
40 |
| Blood flow in coronary arteries 120 minutes following heart attack in 6-month old animals |
48 |
60 |
| Blood flow in aorta (first blood vessel outside the heart) 120-minutes following heart attack in 6-month old animals |
17 |
33 |
| Heart pumping action 2 hours following heart attack in 6-month old animals |
56 |
69 |
Commentary: The recently published study in Molecular & Cellular Biochemistry showing a resveratrol-based nutriceutical (Longevinex®, pronounced long-jev-in-ex)) significantly reduces circulating levels of cholesterol and improved blood circulation in cholesterol-fed rabbits is noteworthy, but probably for reasons other than what most health-minded readers would assume.
Circulating cholesterol levels are not associated with coronary artery disease in healthy individuals, despite what you may have read elsewhere. But the Longevinex® trial IS significant because, in humans, the accumulation of stored iron and copper in the liver leads to fatty liver, a condition that is found in about 35% of American adults. Longevinex® is a matrix of mineral-chelating (key-lay-ting) small molecules derived from botanical sources that is intended to control metallic minerals such as iron and copper, as well as calcium.
A very recent study shows as iron accumulates in the liver with advancing age, several enzymes involved in the natural synthesis of cholesterol are activated in the liver. There is, however, no significant relationship between iron levels in the liver and circulating cholesterol (which is what doctors measure). This means that this Longevinex® study is more pertinent in heading off or reversal of fatty liver than it is any alleged prevention of cholesterol plaque buildup in arteries.
This does not mean that Longevinex® provides no potential benefits for consumers interested in heart health. In fact, Longevinex® is the first branded resveratrol pill to exhibit cardio-protection, that is, protects the heart from damage during a heart attack (animal study), thus averting sudden cardiac death. Resveratrol, a key ingredient in Longevinex®, is also known to thin the blood like aspirin, preventing clots that may block circulation of oxygenated blood to the heart. Resveratrol has been shown to release, before a heart attack, three protective molecules, adenosine, nitric oxide and heme oxygenase, that are otherwise only produced following a heart attack.
If it can be assumed that animal studies are reflective of what goes on in humans, then this study is of some value. However, it is not a real world test. The animals are engorged with a high-cholesterol diet, something that is not particularly reflective of human practice unless one eats a lot of cholesterol-rich eggs every day. Only about 20% of the cholesterol in the human body comes from the diet, the rest is made naturally in the liver. Dietary cholesterol has little impact upon circulating cholesterol levels. Where the modern world went wrong was when refined sugar, not cholesterol, became widely available and laced into all manner of processed foods (bread, salad dressings, ketchup, soups, etc.).
Humans will some day realize they have been conned about cholesterol in order to sell pills. In a healthy state, the liver naturally produces cholesterol. Cholesterol is required for sex drive and procreation since sex hormones (testosterone, estrogen) are synthesized from cholesterol. Cholesterol also transports antioxidants like vitamin E and carotenoids (beta carotene, lutein, lycopene) to tissues, and is needed for mood maintenance. Too-low cholesterol increases the risk for mental depression.
Furthermore, cholesterol is not the primary cause of coronary artery disease or arterial plaque. Only about 3% of plaque found in human arteries is cholesterol, while 50% is calcium. When the French Paradox was first described by Dr. Serge Renaud in the early 1990s, the paradox was that the French consume a relatively high-fat diet and have a bit higher cholesterol levels than North Americans, yet their mortality rate due to coronary artery disease is ~90 per 100,000 versus 240 per 100,000 in the U.S.
But then again, maybe it wasn’t cholesterol that causes coronary artery disease at all! There are a number of studies which now indicate high cholesterol is protective and healthy.
An earlier published animal study showed that resveratrol suppresses arterial plaque without affecting blood cholesterol levels. It is important for consumers to realize resveratrol may be beneficial without affecting cholesterol levels
Please direct your questions regarding Longevinex and resveratrol to info@longevinex.com Bill Sardi, © 2010, Resveratrol Partners LLC
Juhaz B, Das DK, Kertesz A, Juhasz A, Gesztelyi R, Varga B.
Department of Pharmaceutical Sciences, University of Debrecen, Debrecen, Hungary.
The present study examined the efficacy of using Longevinex, a commercially available resveratrol formulation, to lower blood cholesterol in hypercholesteromic rabbits. New Zealand white rabbits were randomly divided into two groups (n = 6 per group), one group was given high cholesterol diet for 3 months while the other group fed regular diet served as control. The high cholesterol diet fed group was further subdivided into two groups (n = 6 per group), one group was given Longevinex resveratrol while the other group given vehicle only served as control. Longevinex was given by gavaging up to a period of 6 months. Longevinex-treated rabbits exhibited lowering of plasma cholesterol level. Inhibition of arterial plaque formation was noticed even after 1 month. Longevinex-treated hearts demonstrated improved ventricular recovery when isolated working hearts were subjected to 30 min of ischemia followed by 2 h of reperfusion. Aortic flow and developed pressure during post-ischemic reperfusion period were significantly higher for the Longevinex-treated hearts compared to those in control group of hearts. Myocardial infarct size was also lower in the treated group compared to that for the untreated group. These results indicate cholesterol-lowering ability of Longevinex, which appears to reflect in its ability to protect the hypercholesteromic hearts from ischemic reperfusion injury. PMID: 21052791
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Sir: I tried to respond to your “placebo effect is bogus” remark at the place you made it, but apparently rebuttal is not allowed. So, I will do so here, though will be surprised if it is published.
Your remark that the “”placebo effect” designation was manufactured “purposefully to discredit dietary supplements” is not in accord with facts. Also, your personal derogation of “placebo effect” as both “imaginary and nonsensical”, both belies the facts of the realities which underly quantum physics; and also studies of brain studies as can be noted by a “wikipedia” search.
Your error does not detract from the usefullness of your product.
thank you.
Longevinex.com:
there is no effort here to silence rebuttal. Sorry for whatever technical problems you faced. I maintain that placebo is a myth. The data that supports placebo would not stand the test of science-based medicine today. -Bill Sardi
If cholestrol is not the culprit in heart disease (which I know) and it is not significantly related to iron in the liver, of what significance (and therefore in the header) is the lowering of cholestrol by Longevinex please?
Longevinex.com:
The molecules in Longevinex inhibit clotting, which is, in the end, what causes all heart attacks. Molecules in Longevinex inhibit adhesion, that is, promotes a smooth inner lining of blood vessels (endothelium) which retards plaque formation. The molecules in Longevinex inhibit calcification, which is the true cause of arterial stiffening and sudden mortal heart attacks. Countries of the world which consume the most calcium-rich dairy products (New Zealand, North America, Ireland, Scandinavia) have the highest rates of cardiovascular disease. The molecules in Longevinex inhibit inflammation, which is involved in arterial aging. The molecules in Longevinex have been shown to stimulate the release of protective molecules (adenosine, heme oxygenase) which protect the heart prior to any heart attack. In the animal lab, Longevinex spared the heart from death, something that aspirin is not doing (about half of the people who succumb to a sudden mortal heart attack were taking a baby aspirin on the day of their demise). The problem in providing a candid answer here is that the FDA says this represents “prevention of disease” which thrusts Longevinex into the category of being a drug. So, I stepped over the FDA censorship line to answer your question. Make no mistake about it, lives are being lost daily because of the misdirection of modern medicine over cholesterol and aspirin as an antidote to heart attacks. Every at-risk cardiac patient should be taking a low-dose resveratrol pill. -Bill Sardi
How would you respond to the recent info out of the SENS Foundation detailing that ramamycin does increase life in non-overweight mice but resveratrol does not extend life in normal weight mice. This is based on several studies showing this same impact of resveratrol….worked on the obese, not on the normal. I feel like the resveratrol I have been taking for two years is in waste and that the ONLY true way to extend life is to continue to get to my targeted caloric restricted weight, the only gold standard for extending life.
Longevinex.com:
Oh, this will be the subject of a longer report. Suffice to say, rapamycin could never be taken by healthy humans. It is a nasty drug fraught with side effects. People would die if they continued taking that pill, but fortunately its side effects cause users to back away. Upcoming reports will continue to question whether resveratrol is a life extender. I am privy to these reports before they get published. Since resveratrol is the molecule that brought us all to this longevity party, reports like these certainly cause mental indigestion, to say the least. The problem, as I see it, is dosage. We saw in the 2008 Baur/Sinclair report that resveratrol did not prolong the life of laboratory mice on a standard calorie diet. In fact, it slightly shortened life span. Doses employed were equivalent to 365 and 1565 mg in a human. Counter this with what is found with red wine. Those who drink 3-5 glasses of dark red wine a day, providing 180-300 mg of wine solids, experience a dramatic reduction in mortality, particularly from heart disease. The idea of the Longevinex pill is to provide the same effect as these wine solids without the alcohol. It is clearly evident that lower doses and combinations of molecules work far more favorably than just plain resveratrol. Not to forget, Longevinex was shown to switch 633 genes in the same direction as a calorie restricted diet — a practice that is known to double the lifespan of all forms of life. This is why I say Longevinex is the closest thing to a calorie restriction mimic known. However, calorie restricted animals do not gain weight with advancing age. Resveratrol-treated or Longevinex-treated laboratory animals do not escape age-related weight gain as do calorie restricted animals (one exception – a recent study did show resveratrol produces weight control, but required the human equivalent of 14,000 mgs to do this). Are we wasting our time taking these pills? No, we will be far healthier, but the question of how to prove these pills prolong human life is the challenge. Because of impracticality, we cannot perform 80-year studies of humans to provide conclusive evidence. But there are markers of aging, namely lipofuscin (accumulation of cellular debris), labile iron (iron within cells), and red blood cell width. Longevinex has already been demonstrated to eradicate lipofuscin from the retina of an older human which correlated with clinical improvement in vision. This not only speaks for slowing aging, it speaks for reversal of aging! My take on all this is that higher doses of resveratrol induce anemia which impairs the immune system and leads to the early demise of laboratory animals. The laboratory animals given high-dose resveratrol tended to succumb to lymphoma, an indicator that the immune response was compromised. The French are living far longer with their beloved red wine. The goal should be to mimic its effects without the inebriation. Stand by for more research. — Bill Sardi