Pronounced long-jev-in-ex
The Official Website
Pronounced long-jev-in-ex
The Official Website
May 11, 2009: by longevinex.com
While scientists believe they are on the frontier of discovering technologies that will produce super longevity, the curse of living longer is looking older. Now a new resveratrol-based dietary supplement — Longevinex Advantage™ – has been designed for adults who want to live longer and look younger.
While Americans have recently heard about the prospect of an anti-aging pill in the form of red wine resveratrol (rez-vair-uh-trawl) pills on both CBS-Sixty Minutes and from Dr. Mehmet C. Oz, MD on the Oprah TV show, longevity has its price — the loss of youthful appearance and activity levels with advancing age. Hair withers, skin wrinkles, joints creak, the voice becomes raspy. Selling longevity has a downside, the inevitable loss of youthful appearance and function, says Bill Sardi, spokesperson for Longevinex®.
Currently made resveratrol pills have one drawback, says Sardi, because they narrowly address cellular aging. The lifespan of humans will still be shortened if connective tissue – the extracellular “goo” that occupies space in between cells – is not maintained. With advancing years tissues lose their elasticity and become dehydrated, which results in visible signs of aging. Furthermore, as connective tissue ages, internal organs such as heart and arteries begin to collapse and lose their elasticity, which still means a rather limited lifespan, says Sardi.
The primary reason for these aging changes is the gradual loss of a key water-gelling molecule called hyaluronan (hi-al-u-ron-an) that serves as a space filler, cushioning and hydrating agent in the skin, eyes, hair and joints. Infants and young females (due to estrogen) have abundant levels of hyaluronan and exhibit soft skin, scarless wound healing, thick hair and extra-flexible joints — the visible signs of youthfulness.
Longevinex Advantage™ provides ingredients that help to restore youthful levels of hyaluronan again. A unique source of pure oral hyaluronan is provided which stimulates fibroblast cells in the body to produce more hyaluronan, along with molecules like resveratrol, quercetin, anthocyanins, catechin and ferulic acid (all known as red wine molecules) that inhibit the enzyme that breaks down hyaluronan (hyaluronidase) and helps to maintain hyaluronan once it is produced.
Surveys show Americans don’t widely embrace the idea of taking anti-aging pills and living longer because of the prospect of living more years with limited mobility, eyesight and mental function. In response to a report in AARP Magazine that an anti-aging pill appears to be on the horizon, most senior Americans responded in an online poll by saying they would not take such a pill because it would increase the quantity of life without maintaining the quality of life. The advent of a dietary supplement like Longevinex Advantage™ that puts “more life in your years rather than just years in your life” is likely to be more broadly welcomed, says Sardi.
In fact, many Americans are more interested in retaining a youthful appearance than they are in living longer. Just look at the number of people who use hair dye, skin creams, wear contact lenses, and elect to undergo plastic surgery, in an effort to retain a youthful appearance. Compare that to the few who practice calorie restriction or take an anti-aging pill to prolong their lifespan, says Sardi.
Americans are living longer. Twenty-five percent of Americans today will live beyond the age of 92. Many Americans have begun to take resveratrol pills like Longevinex®, in hopes of extending their lives another 20 to 30 healthy years. Biologists now say the 120-year lifespan may soon become the norm.
Longevinex® was the first nutriceutical to stabilize resveratrol in a micronized and microencapsulated dietary supplement and has been shown in animal studies to activate far more longevity genes than a calorie-restricted diet or plain resveratrol alone. Longevinex® has also been shown to reduce markers of oxidation and inflammation in a study of endurance athletes. So far, it is the only resveratrol-based supplement to undergo testing.
The combination of resveratrol and hyaluronan is the subject of an applied-for patent. To learn more about Longevinex Advantage™ please visit www.longevinexadvantage.com
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Just wondering where the studies are that show orally administered hyaluronan has any effects. Most studies I’ve read used injections.
Longevinex.com:
Many physicians, including orthopedists, will claim that oral hyaluronan (HA) is too large a molecule to be effectively absorbed. While I would like to see more studies, we know that small amounts of oral HA are absorbed and that HA stimulates hyaluronan-making cells called fibroblasts to produce more HA. It is not desirable to absorb a large percentage of oral HA as it is a thickening agent in the blood and in some patients has raised their blood pressure. More oral HA is made bioavailable if provided with quercetin (that is, more gets past the liver), and quercetin inhibits hyaluronidase, the breakdown enzyme for HA.
I wrote a book about HA a decade ago, citing the dramatic effects oral HA has upon the joints, skin, hair and even the voice box (younger sounding voice). In Japan, it is reported that $4 billion of HA products are used annually, but less than $100 million in the U.S. The Japanese caught wind of the idea of using HA for youthful effects when it was widely reported on ABC News Prime Time Live that people living in a small village in Japan, who were very old, looked very young, had wrinkle-less skin, and were physically active. Dr. Komori, the town doctor, wrote 6 books in Japanese of the youthful phenomenon in villagers in Yuzurihara (called “the village of long life), and attributed their youthfulness to low iron diets and greater production of natural hyaluronan (they didn’t take HA pills). These villagers did consume phyto-estrogens (plant-source estrogen-like molecules) from soy and other vegetables which likely stimulated natural HA production. Quercetin, ferulic acid, EGCG from green tea, and resveratrol are other examples of phytoestrogens and are found in Longevinex Advantage.
The subjective response to the Longevinex Advantage product has been tremendous, with some users claiming they have experienced “facial rejuvenation,” that their friends see noticeable changes in their appearance and even some acquaintances suspect plastic surgery was performed the effect is so dramatic. These positive effects are not uniformly experienced by all, and those consumers who take oral HA products with additional magnesium are likely to experience greater benefit. Longevinex Advantage, while a bit more costly, was developed for those consumers who are searching for youth as well as longevity. As humans, none of us want to live longer just to look older. It is a fact that most people taking anti-aging pills want to hear that they look younger than their peers. -Bill Sardi
Read an article in today’s NYT about Situin and it’s potential in preventing Alzheimer’s. Resveratrol was mentioned as promoting Sirtuin but the artice was not clear if it did so past the brain/blood barrier. I would appreciate if you could shed some light on this.
Longevinex.com’s answer:
http://www.longevinex.com/articles/commentary-on-new-york-times-resveratrol-alzheimers-report/