• Resveratrol-based Nutraceutical (Longevinex®) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies

    July 30, 2008: by longevinex.com

    Nutraceutical Shown To Affect 9-Fold More Longevity Genes Than Resveratrol Or A Limited-Calorie Diet Alone

    – Independent Laboratory Animal Study

    San Dimas, CA · July 30, 2008 /PRNewswire/ – Researchers report that a proprietary nutraceutical matrix (Longevinex®) exhibits striking effects upon genes controlling energy metabolism, nine times broader than research-grade resveratrol and calorie restriction (mouse study- Experimental Gerontology, early online edition, July 2008, for August hard-bound edition) at doses of resveratrol 17-320 fold lower than used in previous animal studies.

    In a breakthrough study using laboratory mice, the matrix of nutraceuticals was found to produce more striking changes in gene expression, and influence more genes, in comparison to mice placed on research-grade resveratrol or a calorie restricted (CR) diet. The nutraceutical matrix favorably affected more biological pathways (by 3-4 fold) compared to CR. The study utilized microrrays which provide data on the expression level of over 20,000 genes. The study was conducted in mouse heart tissue.

    The results of the mouse study were unexpected and surprising, pointing to a synergistic action when multiple natural molecules are employed. The nutraceutical matrix provided red wine molecules resveratrol and quercetin and the rice bran factor known as IP6. All three are mineral-chelating (key-lay-ting) molecules.

    The short-term study not only showed the nutraceutical matrix exerted broader effects upon gene expression than CR or resveratrol, but molecularly mimicked gene patterns typically seen with long-term calorie restriction.

    Of the 2829 genes significantly affected by any of the three dietary interventions employed (CR, resveratrol, or nutraceutical matrix), the limited calorie diet affected about 187 genes (7%), resveratrol about 224 genes (8%), while the nutraceutical matrix influenced 1711 genes (61%), over a 9-fold difference.

    graph: genes effected Longevinex vs resveratrol vs calorie restriction

    Recent studies that have captured the public’s attention have focused on molecules that can slow aging and have been narrowly focused on the sirtuin family of genes and their activation by resveratrol, known as a red wine molecule. Recently researchers have reported that entire gene networks rather than single genes are involved in metabolic disorders, such as elevated blood sugar and cancer. Researchers report that gene array testing can detect genes affected by an unhealthy diet before there is change shown in the blood sample. [Nature March 16, 2008]

    The nutraceutical matrix of natural molecules (Longevinex®) exhibited a much broader impact upon gene expression and more strikingly affected key genes, like Pdk4 and Pgc1 alpha, involved in mitochondrial energy metabolism.

    Only the nutraceutical matrix, and not resveratrol or a long-term calorie restricted diet, upregulated the Foxo1 gene which enters the cell nucleus and promotes the expression of key longevity genes.

    These effects were accomplished with a relatively low human equivalent dose of resveratrol. At about 1/15th the dose employed in a prior widely acclaimed mouse study (Nature Magazine Nov. 1, 2006) the nutraceutical matrix was able to exert more demonstrable genomic effects.

    Prior animal studies employed the human equivalent of 1565, 360 and 343 milligrams of resveratrol to produce longevity effects. The nutriceutical matrix exerted 9-fold greater effect over the mouse genome at the equivalent daily human dose of resveratrol of 100 milligrams per day. According to this study, if data from mice is applicable to humans, some widely promoted mega-dose resveratrol pills, providing 500 to 1000 milligrams of resveratrol, would not exert as broad an effect over the human genome as the lower-dose resveratrol when provided in a matrix of other mineral-chelating natural molecules.

    Gene Chip
    The discovery was made utilizing laser scanning technology to measure levels of messenger-RNA from thousands of genes in tissues obtained from test animals. Researchers used a commercially available GeneChip® (Affymetrix), which is about the size of a credit card.

    Mice and humans share about 99% of their 30,000 genes. Most gene expression changes caused by aging are partially or completely prevented by CR. This discovery is suggestive of a day when humans could molecularly avert the effects of over-eating as well as slow or even reverse the aging process without having to deprive themselves of food.

    A life-long CR diet is anticipated to influence more than the 200 genes shown in this short-term study, but the nutraceutical matrix exerted influence much sooner, raising the possibility that adherence long-term CR may not be required to obtain the same benefits.

    The study was sponsored by Resveratrol Partners LLC, maker of Longevinex®, a patent-applied-for nutraceutical ( www.longevinex.com).

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