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Resveratrol Prolongs Life of Lab Mice
Resveratrol Prolongs Lifespan
Copyright 2008 Bill Sardi, Resveratrol Partners LLC
In the recent published report in Cell Metabolism (Volume 8, pages 1–12, August 6, 2008), many users of resveratrol pills were surprised to find that resveratrol did not prolong the lifespan of laboratory mice placed on a standard lab-chow diet (SD).
The researchers compared the effects on laboratory mice of an every-other-day limited calorie diet (EOD), a high-fat/high-calorie diet (HC) and a standard diet (SD) with and without resveratrol. Resveratrol was given at two different doses, equivalent in humans to 360 mg lower-dose resveratrol (LR) and 1565 milligrams (R) per day.
While the resveratrol-fed mice exhibited dramatically improved parameters of health, the fact these animals fed a standard diet did not live longer on resveratrol led many longevity seekers to ask why they are taking resveratrol pills at all.
In a follow-up study to the widely publicized 2006 mouse/resveratrol study published in Nature Magazine (November 1, 2006), researchers now provide more complete long-term analysis of the biological effects of resveratrol as a molecular mimic of calorie restriction in animals.
The results, published in the journal Cell Metabolism, are jaw-dropping, but they also come with a surprise. Resveratrol-fed elderly mice show a marked reduction in signs of aging, including:
• Reduced albumin (a blood protein; elevated albumin often occurs with heart failure)
• Decreased inflammation
• Superior blood-vessel health
• Increased elasticity of the aorta (the first blood vessel outside the heart)
• Greater balance and coordination (motor function)
• Strikingly reduced cataract formation (even better than a reduced-calorie diet)
• Preserved bone mineral density.
Source: Artés-Hernández F, Artés F, Tomás-Barberán FA. Quality and enhancement of bioactive phenolics in cv. Napoleon table grapes exposed to different postharvest gaseous treatments. J Agric Food Chem. 2003 Aug 27;51(18):5290-5.
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