Pronounced long-jev-in-ex
The Official Website
Pronounced long-jev-in-ex
The Official Website
February 5, 2012: by Bill Sardi
As many Longevinex® users already know, we have taken special measures to protect the active form of resveratrol (trans resveratrol) from exposure to light and oxygen by microencapsulation (enfolding it within plant starches and dextrins) so as to prevent it from turning into its degraded (cis resveratrol) form. However, exposure to another environmental agent was not anticipated – political heat.
As I write, landmark reports in journals showing how well resveratrol and Longevinex® limit damage to the heart in the event of a heart attack, to the point of turning an otherwise mortal attack into a survivable event, are being expunged from the scientific record, retracted in the wake of a scientific witch hunt against a researcher who dared to cooperate with a dietary supplement company.
Despite on-the-record testimony from various resveratrol researchers that the allegedly falsified activities have no bearing on the conclusions drawn from these experiments, the university where these experiments were conducted continues to contact journal editors, demanding they withdraw these papers from publication. So now we get a clear picture of the ultimate objective – to eradicate resveratrol research from the scientific record. Some of this research involved Longevinex®.
Posted in Longevinex, Resveratrol, Studies ; No Comments »
January 26, 2012: by admin
Experimentally-induced heart attack in laboratory mice produced scarred heart on left (white areas) while Longevinex®-treated mice exhibit less scarring as measured in the bar charts presented above the heart images.
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January 12, 2012: by admin
Las Vegas, NV (Jan 11, 2012) – Bill Sardi, managing partner for Longevinex®, a resveratrol-based dietary supplement, says the product his company makes has passed independent scientific scrutiny in human studies conducted both in the USA and overseas and that the animal-lab researcher at the University of Connecticut who has conducted studies involving Longevinex® and whose work has now come under scientific scrutiny, has no business relationship with Longevinex®.
Sardi says, to his knowledge, criticism of Dr. Dipak Das’ work at the University of Connecticut primarily involves irregularities in a test called the western blot analysis which would not alter the findings that Longevinex® has been proven to reduce the area of scar tissue following a heart attack in excised rodent hearts.
Actual photographs showing the amount of scarring following a heart attack provide incontrovertible evidence that both resveratrol and Longevinex® protect the rodent heart prior to a heart attack by activating protective molecules such as nitric oxide, adenosine and heme oxygenase prior to a heart attack, says Sardi.
“None of the allegations that I have briefly read in newspapers negate the pioneering work of Dr. Das, who first showed that resveratrol can turn a mortal heart attack in animals into a non-mortal event,” says Sardi. The implications of this discovery are profound given that aspirin has just recently been found to be ineffective in reducing the risk of a mortal heart attack in humans, adds Sardi.
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December 9, 2011: by longevinex.com
At no extra cost to consumers, Longevinex® now features DNA REPAIR FACTOR in its formula to enhance DNA repair by provision of supplemental DNA parts called nucleotides (adenine, guanine, cytosine, thymine, uridine).
When there aren’t enough nucleotides available this can lead to chromosomal instability, shortening of telomeres (end-caps on chromosomes) and defective DNA repair.
Given to astronauts on space missions to boost their immune response and to prematurely-born infants to facilitate growth, supplemental nucleotides are the lettered (A, G, C, T) parts of the coiled DNA ladder (adenine, guanine, cytosine, thymine, uridine).
A recent discovery reveals a shortage of DNA parts can lead to errors in DNA repair and subsequent gene mutations. Living cells are forced to abnormally increase in numbers when there is an insufficient pool of nucleotide spare parts to support normal DNA replication.
Supplemental nucleotides also work in tandem with resveratrol, a red wine molecule that exerts control over c-Myc, a master regulator of many genes that are involved in DNA replication.
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June 29, 2011: by Bill Sardi
* SOD = superoxide dismutase
Genes they be — a Sirtuin family of seven “silent information regulators” that are guardians of the cell. Sirtuins have been linked with prolonged lifespan in various life forms, starting with yeast cells, fruit flies and roundworms.1
Posted in Longevinex, Resveratrol, Sirtuin 1 Gene ; No Comments »
December 31, 2010: by Bill Sardi
It was a year Americans learned why “their genes are not their biological destiny.”
It was the year Americans began to be sales pitched on the idea of using home test kits to identify gene derived maladies.
It was a year when biologists continued to point in all directions, claiming there are 300 theories of why humans age and they still don’t have any idea which one is correct.
It was the year when the promise of a red wine resveratrol anti-aging pill was “short lived.” But did this pill fizzle, or was it being swept under the rug?
It was the year of the downfall of the Sirtuin1 gene as the “holy grail” of anti-aging.
It was the year telomeres — those end caps on chromosomes — intrigued many and early adaptors excitedly searched for telomere lengthening agents — yet telomeres may just be another misdirection. Maybe longevity seekers ought to be looking at molecules that prevent double-strand DNA breaks rather than telomere lengtheners.
It was a year where mTOR inhibitor drugs (whatever they are) began to be mentioned in place of resveratrol as an anti-aging pill. Yet the mTOR inhibitor drug rapamycin is fraught with side effects and could never be used in a healthy population.
It was a year when microRNA began to be recognized as the predominant way our genes are switched on and off.
It was a year when funding for anti-aging technologies began to dry up and the prospect of an anti-aging pill began to fade.
Posted in Longevinex, Resveratrol ; 13 Comments »
December 29, 2010: by longevinex.com
Las Vegas, Nevada (Dec. 29, 2010) – It was Paracelsus, the Renaissance physician (1493-1541 A.D.) who first said “the dose makes the poison.” So, you can drink too much wine, or ingest too much resveratrol, but in an unprecedented study, heart researchers report they couldn’t find a toxic dose for Longevinex®, a resveratrol-based dietary supplement.
Investigators previously reported that six or more glasses of red wine per day actually increase the risk, whereas 3-5 glasses per day optimally reduce risk for cardiac death. This is the well-known J-shaped risk curve (risk goes down, then up with excessive dose) that has been documented for both red wine and resveratrol.
North Americans who abstain from drinking wine have higher mortality rates for coronary heart disease (~240 per 100,000), making red wine and resveratrol pills tantalizing for those individuals who wish to reduce their risk for a mortal heart attack (~90 per 100,000 for wine drinkers).
The drawback here is that consumption of 3-5 glasses of red wine a day approaches the point of inebriation. Health seekers who wish to avoid the undesirable effects of alcohol may be led to try resveratrol pills, which if taken in mega-doses, could be potentially toxic to the heart.
Posted in Dosage, Longevinex, Resveratrol, Studies ; 2 Comments »
December 24, 2010: by Bill Sardi
Las Vegas, NV (Dec. 24, 2010) – In the world’s first comparative microRNA analysis of a resveratrol-based nutriceutical, Longevinex®, a low-dose resveratrol-based dietary supplement, exhibited a distinctive gene regulation pattern apart from plain resveratrol and protected the excised animal heart from damage caused by an experimentally-induced heart attack.
Three weeks of oral resveratrol or Longevinex® ingestion prior to an induced heart attack returned microRNA activity close to their pre-event levels. Among thousands of microRNA’s studied, just six were attributed to exerting the majority of the gene-switching effects measured in the animal heart study — four microRNA optimally regulated by Longevinex® and two optimally by plain resveratrol.
A pre-conditioning effect with resveratrol and Longevinex® had already been demonstrated in prior studies where these small molecules activate antioxidant defenses (nitric oxide, heme oxygenase, adenosine) prior to a heart attack, thus limiting damage in the event of an abrupt halt in the delivery of oxygenated blood to the heart.
This newly published study in the PLoS ONE (Public Library of Science) journal sought to compare and contrast the gene switching pattern for both plain resveratrol and resveratrol in a matrix with other small molecules (Longevinex®) following an induced blockage of circulation in excised animal hearts.
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: by Bill Sardi
While the public has been awestruck over the idea of controlling genes via nutrients, or what is called epigenetics, it is clear we have a more accurate picture here of gene activation using microRNA analysis. And here we see, for the first time, some of the magic in red wine that has been captured in a pill. While biologists have focused their research studies on plain resveratrol, the advantageous synergism of an array of small molecules, similar to that provided in red wine, is clearly demonstrated in this animal experiment conducted at National Institute of Health laboratories.
While the evidence for molecular preconditioning the heart to withstand a heart attack using resveratrol is growing, there is unexplained lack of interest from cardiologists. Given that safety concerns are answered, there is little standing in the way of cardiologists beginning to prescribe resveratrol pills today.
A lone cardiologist who has extensively prescribed Longevinex® indicates there have been no significant side effects among hundreds of his patients. Thousands of Americans are taking resveratrol pills in an unguided fashion without reported serious side effects, which is a safety study of sorts. Furthermore, physicians may mistakenly demand human studies be conducted before they prescribe for their patients. However, this is impractical.
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November 20, 2010: by Bill Sardi
Mice lacking the Sirtuin3 gene develop hearing loss via the production of free radicals that damage the power plants (mitochondria) within living cells, said researchers in a newly published report in the journal CELL today.
Researchers report the Sirtuin3 gene is essential in producing the health and longevity effects of a limited calorie diet. The Sirtuin3 gene increases antioxidant activity (glutathione, pronounced glu-tah-thigh-on) in mitochondrial compartments within living cells, thus preventing age-related hearing loss. The mitochondria are small organelles that are found within living cells that produce cellular energy in the form of adenosine triphosphate (ATP).
So far Sirtuin3 has taken a back seat to Sirtuin1 in longevity research, but possibly the entire family of Sirtuin “survival genes” will eventually be linked to longevity mechanisms. The entire research report can be viewed here.
Posted in Longevinex, Resveratrol, Sirtuin 1 Gene ; No Comments »